HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1-butanol → [2-(4-Hydroxybutyl]amino-2-oxoethoxy]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1-butanol | HCID 25868 | — |
| Reactant | 1,4-Dioxane-2,6-dione | HCID 78232 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Product | [2-(4-Hydroxybutyl]amino-2-oxoethoxy]acetic acid | HCID 20558906 | — |
Reaction Steps
methanesulfonate by (a) reacting diglycolic anhydride and 4-aminobutanol to produce [2-(4-hydroxybutyl]amino-2-oxoethoxy]acetic acid, (b) heating to cyclize the latter to obtain 4-(4-hydroxybutyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 4-(3,5-dioxomorpholino)butyl methanesulfonate and (d) reacting the mesylate with 3-[bis(4-butoxy-o-tolyl)methyl]piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04197315 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-bc56aa5dea8145d889e5aa4627f403d8 |
| Source note | uspto-grants-1980_04 |