HCID 86736928, compound → HCID 12796475, compound

Participants

Reaction Steps

A solution of (Z)-3α-hydroxy-5α-pregn-17(20)-en-11-one oxime (9.638 g) in propan-1-ol (200 ml) was refluxed under N2 whilst Na (9.6 g) was added portionwise. When all of the Na had reacted, about 90 ml propan-1-ol was distilled and then the residue was poured into water, ice was added and the crystalline solid (9.19 g) was collected by filtration. A portion (6.17 g) was crystallised from ethanol-water to afford title compound (3.6 g), m.p. 118°-125°, [α]D +5.4°.

Provenance & Evidence