反应详情

Ethyl 5-mercapto-1H-tetrazol-5-ylacetate (15.0 g) was dissolved in ethanol (50 ml), the solution was saturated with ammonia gas then set aside for 36 hours. The precipitated mass was collected, washed with ethanol (20 ml), dried and dissolved in water (100 ml). The solution was treated with decolourising charcoal, filtered, acidified with concentrated hydrochloric acid and cooled in an ice bath. The product crystallised as needles and was collected, washed with a little water and dried in vacuo, 9.51 g., (75.0%) m.p. 214°-216° C. (d), νmax (nujol) 1695 cm-1 ; δ[(CD3)2SO], 7.72 (2H,d, J=22 Hz, --NH2), 5.02 (2H,s, --CH2 --). Found: C, 22.39; H, 2.18; N, 43.82; S, 20.16. C3H5N5OS requires: C, 22.64; H, 3.17; N, 44.00; S, 20.14%.

1. customThe precipitated mass was collected
2. washwashed with ethanol (20 ml)
3. customdried
4. dissolutiondissolved in water (100 ml)
5. additionThe solution was treated with decolourising charcoal
6. filtrationfiltered
7. temperaturecooled in an ice bath
8. customThe product crystallised as needles
9. customwas collected
10. washwashed with a little water
11. customdried in vacuo, 9.51 g