Acetone-D6 → HCID 70589080, compound

Participants

Reaction Steps

Prepared from sodium cephalothin and N,N-dimethyl-5-mercapto-1H-tetrazol-1-ylacetamide as described in example 12(b) in 44.1% yield; t.l.c. (SiO2 ; B.A.W; 12:3:5) Rf=0.35; λmax (95% ethanol) 271 nm (ε 8,390); δ(free acid) [(CD3)2CO] 2.33 and 3.27 (6H, 2×s -N(CH3)2), 3.85 (2H,s, C2 methylene), 4.00 (2H,s, --CH2CO--), 4.47 (2H,bs, --CH2S--), 5.20 (1H,d, J 5 Hz, C6 proton), 5.55 (2H,s, --CH2CON(CH3)2), 5.97 (1H,dd, J 5 and 9 Hz, C7 proton), 6.9-8.0 (4H,m, thienyl protons and --CO2H), 8.29 (1H,d, J 9 Hz, --CONH--).

Provenance & Evidence