Sodium Cyanide → HCID 20344097, compound

HRID 2049631Notes

Reaction equation

HRID 2049631 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1.[C-:17]#[N:18].[Na+]>C(O)C.O>[F:16][C:12]1[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=1)[O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][C:17]#[N:18]

Participants

5

Reactant 2

HCID 8929Sodium CyanideHCID 20344102HCID 20344102, compound

Product 1

HCID 20344097HCID 20344097, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

1-(Chloromethyl)-2-(3-fluorophenoxy)benzene (26.5 g.) was dissolved in 300 ml of ethanol; a solution of sodium cyanide (7.8 g.) in 15 ml of water was added, and the resulting mixture was heated to reflux overnight. The ethanol was evaporated, the residue taken up in water, extracted with ether and the combined ether extracts were dried and concentrated to give the title compound. ##STR13##

Workup

  1. temperaturethe resulting mixture was heated
  2. temperatureto reflux overnight
  3. customThe ethanol was evaporated
  4. extractionextracted with ether
  5. dry with materialthe combined ether extracts were dried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-80b7f065ce434db98481f731fca32278
Source dataset
uspto-grants-1980_04
Patent number
US04198421

Reaction notes

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