反应详情

11.8 g of lithium aluminum hydride are added portionwise at 0° with stirring to 144.8 g of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyliden)ethanone dissolved in 1.4 liters of tetrahydrofuran. 30 minutes after completion of the addition, 300 ml of water are cautiously added dropwise, with cooling; then 800 ml of diethyl ether are added, and the organic phase is collected. The organic phase is dried over sodium sulfate, the solvent is removed by evaporation, and the oily residue is distilled under a vacuum to obtain 127 g (87% of theory) of the title compound:

1. additionare cautiously added dropwise
2. temperaturewith cooling
3. customthe organic phase is collected
4. dry with materialThe organic phase is dried over sodium sulfate
5. customthe solvent is removed by evaporation
6. distillationthe oily residue is distilled under a vacuum