Acetic Anhydride → 2-Pyrrolidineethanol, alpha-(3-methoxyphenyl)-1-methyl-, acetate (ester), (R*,S*)-

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Reaction Steps

3,5 g of (R*,S*)-1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)-ethanol and 40 ml of acetic acid anhydride are stirred for 15 minutes at room temperature. 6 N sodium hydroxide solution is added with cooling up to a pH of 8-9. The mixture is extracted with diethyl ether, and the organic layer is concentrated to the oily title compound. The hydrochloride (from methanol/diethyl ether) melts at 155°-157°.

Provenance & Evidence