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Water → 1-Hexanoic acid-[1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)-ethyl]-ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Hexanoyl chloride | HCID 67340 | — |
| 反応物 | 1-(3-Methoxyphenyl)-2-(1-methylpyrrolidin-2-yl)ethan-1-ol | HCID 3054349 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Hexanoic acid-[1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)-ethyl]-ester | HCID 20344129 | 90.5% |
反応手順
A solution of 0.7 g of hexanoyl chloride in 10 ml of methylene chloride is added drop by drop to a mixture of 1.17 g of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)-ethanol and 0.5 g of triethyl amine in 20 ml methylene chloride. The mixture is stirred for 2 hours and subsequently treated with water. The organic phase is separated, dried over sodium sulphate and concentrated. There are obtained 1.5 g of the title compound as tough, light oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04198424 |
| 出典データセット | uspto-grants-1980_04 |
| ORD ID | ord-d578435671164de881bedb78e212d1c8 |
| 出典メモ | uspto-grants-1980_04 |