Thionyl Chloride → HCID 20343950, compound

HRID 2049676Notes

Reaction equation

HRID 2049676 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:10](O)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].S(Cl)([Cl:28])=O>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:10]([Cl:28])=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 20343955HCID 20343955, compound

Product 1

HCID 20343950HCID 20343950, compound

Procedure

A suspension of 3.4 g of 1-acetyl-4-(2-phenylthiophenyl)piperidine-4-carboxylic acid in 5 ml of freshly distilled thionyl chloride is warmed on a steam bath for 5 minutes to effect a clear solution. Any excess thionyl chloride is removed at 50° C. under reduced pressure. The residue is recrystallized from a benzene-cyclohexane mixture to provide 1-acetyl-4-(2-phenylthiophenyl)piperidine-4-carbonyl chloride.

Workup

  1. temperatureis warmed on a steam bath for 5 minutes
  2. customAny excess thionyl chloride is removed at 50° C. under reduced pressure
  3. customThe residue is recrystallized from a benzene-cyclohexane mixture

Sources & evidence

ORD record
ord-9c632406782c49d99e386e823dd5c6bc
Source dataset
uspto-grants-1980_04
Patent number
US04198420

Reaction notes

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