Aluminum(III) Chloride → HCID 20344040, compound

Participants

Reaction Steps

A solution of 14 g of 1-acetyl-4-(2-phenylthiophenyl)piperidine-4-carbonyl chloride in 500 ml of methylene chloride is slowly added with stirring to 7.5 g of aluminum chloride. After total addition, the reaction mixture is refluxed for 2 hours. Thereafter, ice is added before extracting thrice with chloroform. The combined chloroform extracts are successively washed with dilute alkali, washed with water, dried and the solvent is removed under vacuum, providing 10,11-dihydro-1'-acetyl-11-oxospiro[dibenz(b,f)thiepin-10,4'-piperidine].

Provenance & Evidence