Acetic Anhydride → HCID 20343984, compound

Participants

Reaction Steps

A mixture of 0.7 g of 4-[2-(4-fluorophenylthio)phenyl]piperidine-4-carboxylic acid and 0.83 ml of acetic anhydride in 4.2 ml of pyridine is stirred at reflux for 4 hours. Thereafter, the excess pyridine is removed by rotary evaporation and the residue is taken up in 10 ml of water, where it is treated with 10 ml of 1 N hydrochloric acid. The acidic mixture is extracted thrice with 20 ml portions of an ether-benzene (1:1) mixture and the combined extracts are successively washed twice with 40 ml portions of water, washed once with a 15 ml portion of a saturated sodium chloride solution and dried. The resulting residue is recrystallized from an acetone-ether (1:4) mixture providing 1-acetyl-4-[2-(4-fluorophenylthio)phenyl]piperidine-4-carboxylic acid.

Provenance & Evidence