Ethyl bromoacetate → HCID 54470314, compound

HRID 2049697Notes

Reaction equation

HRID 2049697 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]=[CH:11][C:12](=[O:14])[CH3:13])=[CH:4][CH:3]=1.Br[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>[Zn]>[OH:14][C:12]([CH3:13])([CH:11]=[CH:10][CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 57243761HCID 57243761, compound

Product 1

HCID 54470314HCID 54470314, compound

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Using 7.17 g of 6-(p-chlorophenyl)-3-hexen-2-one, 4.2 ml of ethyl bromoacetate and 2.47 g of zinc, the reaction and the purification of the product were carried out according to the method described in Example 1 (a) affording 6.4 g of ethyl 3-hydroxy-3-methyl-7-(p-chlorophenyl)-4-heptenoate.

Workup

  1. customthe reaction
  2. customthe purification of the product

Sources & evidence

ORD record
ord-6370fa7ed5a64eb9a1646dd7701b4984
Source dataset
uspto-grants-1980_04
Patent number
US04198425

Reaction notes

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