Ethyl bromoacetate → HCID 54152476, compound

HRID 2049700Notes

Reaction equation

HRID 2049700 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH:17]=[CH:18][C:19](=[O:21])[CH3:20])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>[Zn]>[OH:21][C:19]([CH3:20])([CH:18]=[CH:17][CH2:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:10][CH:11]=1)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 57147667HCID 57147667, compound

Product 1

HCID 54152476HCID 54152476, compound

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Using 25.83 g of 6-(p-benzyloxyphenyl)-3-hexen-2-one, 11.3 ml of ethyl bromoacetate and 6.63 g of zinc, the reaction and the purification of the product were carried out according to the method described in Example I (a) affording 29.6 g of ethyl 3-hydorxy-3-methyl-7-(p-benzyloxyphenyl)-4-heptenoate.

Workup

  1. customthe reaction
  2. customthe purification of the product

Sources & evidence

ORD record
ord-99adfa7e60b94c748d59aeeaa074066d
Source dataset
uspto-grants-1980_04
Patent number
US04198425

Reaction notes

Loading…