Ethyl bromoacetate → HCID 53891936, compound

HRID 2049706Notes

Reaction equation

HRID 2049706 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH:17]=[CH:18][C:19](=[O:21])[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>[Zn]>[OH:21][C:19]([CH3:20])([CH:18]=[CH:17][CH2:16][CH2:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 57161855HCID 57161855, compound

Product 1

HCID 53891936HCID 53891936, compound

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Using 2.42 g of 6-(o-benzyloxyphenyl)-3-hexen-2-one, 1.8 ml of ethyl bromoacetate and 1.1 g of zinc, the reaction and the purification of the product were carried out according to the method described in Example 1 (a) affording 2.9 g of ethyl 3-hydroxy-3-methyl-7-(o-benzyloxyphenyl)-4-heptenoate.

Workup

  1. customthe reaction
  2. customthe purification of the product

Sources & evidence

ORD record
ord-dfec5e0b618548ee9268d1d2d742a924
Source dataset
uspto-grants-1980_04
Patent number
US04198425

Reaction notes

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