Ethyl bromoacetate → HCID 54379328, compound

HRID 2049714Notes

Reaction equation

HRID 2049714 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH:17]=[CH:18][C:19](=[O:21])[CH3:20])=[CH:11][C:10]=1[O:22][CH3:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>[Zn]>[OH:21][C:19]([CH3:20])([CH:18]=[CH:17][CH2:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[C:10]([O:22][CH3:23])[CH:11]=1)[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 57141922HCID 57141922, compound

Product 1

HCID 54379328HCID 54379328, compound

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Using 1.19 g of 6-(p-benzyloxy-m-methoxyphenyl)-3-hexen-2-one, 0.64 ml of ethyl bromoacetate and 0.33 g of zinc, the reaction and the purification of the product were carried out according to the method described in Example 25 (a) affording 1.28 g of ethyl 3-hydroxy-3-methyl-7-(p-benzyloxy-m-methoxyphenyl)-4-heptenoate.

Workup

  1. customthe reaction
  2. customthe purification of the product

Sources & evidence

ORD record
ord-505d476c50c141a8a345a38eba8fe13a
Source dataset
uspto-grants-1980_04
Patent number
US04198425

Reaction notes

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