Ethyl bromoacetate → HCID 54078893, compound

HRID 2049717Notes

Reaction equation

HRID 2049717 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH:18]=[CH:19][C:20](=[O:22])[CH3:21])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26]>[Zn]>[OH:22][C:20]([CH3:21])([CH:19]=[CH:18][CH2:17][CH2:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:10][CH:11]=1)[CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 57223497HCID 57223497, compound

Product 1

HCID 54078893HCID 54078893, compound

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Using 0.68 g of 7-(p-benzyloxyphenyl)-3-hepten-2-one, 0.37 ml of ethyl bromoacetate and 0.19 g of zinc, the reaction and the purification of the product were carried out according to the method described in Example 25 (a) affording 0.84 g of ethyl 3-hydroxy-3-methyl-8-(p-benzyloxyphenyl)-4-octenoate.

Workup

  1. customthe reaction
  2. customthe purification of the product

Sources & evidence

ORD record
ord-a83a3a45b1b14643947dbe6130b32126
Source dataset
uspto-grants-1980_04
Patent number
US04198425

Reaction notes

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