Sodium Hydroxide → HCID 12878302, compound

HRID 2049718Notes

Reaction equation

HRID 2049718 reaction equation
[Br:1]Br.[OH:3][C:4]([CH3:30])([CH:11]=[CH:12][CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:18][CH:17]=1)[CH2:5][C:6]([O:8]CC)=[O:7].[OH-].[Na+]>C(O)C>[OH:3][C:4]1([CH3:30])[CH:11]([Br:1])[CH:12]([CH2:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:18][CH:17]=2)[O:8][C:6](=[O:7])[CH2:5]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 54078893HCID 54078893, compound

Product 1

HCID 12878302HCID 12878302, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the method described in Example 25 (b), the reaction was carried out by using 0.13 ml of bromine and 0.74 g of the carboxylic acid which was prepared from 0.80 g of ethyl 3-hydroxy-3-methyl-8-(p-benzyloxyphenyl)-4-octenoate, 8 ml of ethanol and 1 ml of 4N sodium hydroxide, and the product was recrystallized from ethyl ether to give 0.32 g of the desired compound melting at 100°-101° C.

Workup

  1. customthe product was recrystallized from ethyl ether

Sources & evidence

ORD record
ord-93d7990a7ebb4965a75009a9b817a586
Source dataset
uspto-grants-1980_04
Patent number
US04198425

Reaction notes

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