Benzoylacetone → HCID 12339501, compound

HRID 2049738Notes

Reaction equation

HRID 2049738 reaction equation
[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)[C:3]#[N:4].[C:12]([CH2:20][C:21](=O)[CH3:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C.C(OCC)C>[NH2:4][C:3]1[C:20]([C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:21]([CH3:22])[NH:1][C:2]=1[C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 7166BenzoylacetoneHCID 27359222-Amino-2-(4-fluorophenyl)acetonitrile

Product 1

HCID 12339501HCID 12339501, compound

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

Starting from 2-amino-2-(p-fluorophenyl)acetonitrile and benzoyl acetone, the open-chain intermediate compound is obtained, b.p. 120° C./0.2 mm Hg. The title compound is obtained in a 66% overall yield, m.p. 209°-10° C. (from ethanol/diethyl ether).

Workup

  1. customthe open-chain intermediate compound is obtained

Sources & evidence

ORD record
ord-e9cf449cbd4544bf8357afe27c7a90db
Source dataset
uspto-grants-1980_04
Patent number
US04198502

Reaction notes

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