HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 3-Amino-4,5-dicarbomethoxy-2-(p-chlorophenyl)pyrrole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Dimethyl acetylenedicarboxylate | HCID 12980 | — |
| Reactant | HCID 11309731 | HCID 11309731 | — |
| Solvent | Diethyl ether methanol | HCID 21864698 | — |
| Product | 3-Amino-4,5-dicarbomethoxy-2-(p-chlorophenyl)pyrrole hydrochloride | HCID 12339492 | — |
Reaction Steps
Starting from 2-amino-2-(p-chlorophenyl)acetonitrile and dicarbomethoxyacetylene, the open-chain intermediate compound is obtained, m.p. 74°-76° C. (from diethyl ether). The title compound is obtained in a 48% overall yield, m.p. 216°-8° C. (from methanol/diethyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04198502 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-4a10edd899584959806b3bad7ac9ad14 |
| Source note | uspto-grants-1980_04 |