Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate → Ethyl 4-methylpiperazine-2-carboxylate

HRID 2049750Notes

Reaction equation

HRID 2049750 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH:9]1[C:15]([O:17][CH2:18][CH3:19])=[O:16])C1C=CC=CC=1>[Pd]>[CH3:14][N:11]1[CH2:12][CH2:13][NH:8][CH:9]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10]1

Participants

3

Reactant 1

HCID 10563447Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

Product 1

HCID 12558522Ethyl 4-methylpiperazine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

13.1 g. of 1-benzyl-4-methylpiperazine-2-carboxylic acid, ethyl ester in 100 ml. of absolute alcohol and 3 g. of palladium on charcoal are shaken at room temperature and 50 psi for 41/2 hours. The catalyst is filtered off and the residue is distilled to obtain 4-methylpiperazine-2-carboxylic acid, ethyl ester, b.p. 0.3 mm 84°-86°.

Workup

  1. custom2 hours
  2. filtrationThe catalyst is filtered off
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-046bc07a9dda4d92858229e36825253a
Source dataset
uspto-grants-1980_04
Patent number
US04198509

Reaction notes

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