HCID 20344437, compound → HCID 20344445, compound

HRID 2049779Notes

Reaction equation

HRID 2049779 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([C:17]#[N:18])[CH2:10][CH2:11][C:12](OCC)=[O:13])=[CH:4][CH:3]=1>[Ni]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]2[CH2:17][NH:18][C:12](=[O:13])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 20344437HCID 20344437, compound

Product 1

HCID 20344445HCID 20344445, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

In the same manner as Example 1-(d), 5 g of ethyl 5-(4-chlorophenyl)-4-cyanovalerate was reduced with Raney's nickel as the catalyst to obtain 5-(4-chlorobenzyl)-2-piperidinone.

Sources & evidence

ORD record
ord-c2e1a9aa03c543d980051c54a0a62671
Source dataset
uspto-grants-1980_04
Patent number
US04198514

Reaction notes

Loading…