HCID 20344430, compound → HCID 20344424, compound

HRID 2049781Notes

Reaction equation

HRID 2049781 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([C:16]#[N:17])[CH2:10][C:11](OCC)=[O:12])=[CH:4][CH:3]=1>[Ni]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]2[CH2:16][NH:17][C:11](=[O:12])[CH2:10]2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 20344430HCID 20344430, compound

Product 1

HCID 20344424HCID 20344424, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

In the same manner as Example 1-(d), 10 g of ethyl 4-(4-fluorophenyl)-3-cyanobutyrate was catalytically reduced with the acid of Raney's nickel to obtain 4-(4-fluorobenzyl)-2-pyrrolidinone.

Sources & evidence

ORD record
ord-91ac539ac3f446a08424c0443746fdd2
Source dataset
uspto-grants-1980_04
Patent number
US04198514

Reaction notes

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