HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester → 4,5-dihydro-4-chloro-1-(2-mercaptoacetyl)-1H-pyrrole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester | HCID 103458 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| Reactant | 4-Chloroproline | HCID 22810642 | — |
| Reactant | Acetylthioacetylchloride | HCID 23301560 | — |
| Reactant | 4-chloro-L-proline tertbutyl ester | HCID 57117873 | — |
| Product | 4,5-dihydro-4-chloro-1-(2-mercaptoacetyl)-1H-pyrrole-2-carboxylic acid | HCID 23343196 | — |
Reaction Steps
By substituting 4-chloro-L-proline tert-butyl ester [prepared from 4-chloro-L-proline by the procedure described in J.Am. Chem. Soc., 82, 3359 (1960) for L-proline] for the L-proline tert-butyl ester and 2-acetylthioacetyl chloride for the 3-acetylthio-2-methylpropanoyl chloride in the procedure of Example 1 and then submitting the product to the procedure of Example 2, 4,5-dihydro-4-chloro-1-(2-mercaptoacetyl)-1H-pyrrole-2-carboxylic acid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04198515 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-c26e1ee94c1d468fa166b241cd2bf36c |
| Source note | uspto-grants-1980_04 |