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Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester → (+/-)-4,5-dihydro-4-ethoxy-(2-mercapto-1-oxopropyl)-1H-pyrrole-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester | HCID 103458 | — |
| 反応物 | L-Proline | HCID 145742 | — |
| 反応物 | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| 反応物 | Acetylthioacetylchloride | HCID 23301560 | — |
| 反応物 | 4-ethoxy-L-proline | HCID 54352148 | — |
| 反応物 | 4-ethoxy-L-proline tert-butyl ester | HCID 57282194 | — |
| 生成物 | (+/-)-4,5-dihydro-4-ethoxy-(2-mercapto-1-oxopropyl)-1H-pyrrole-2-carboxylic acid | HCID 23343183 | — |
反応手順
By substituting 4-ethoxy-L-proline tert-butyl ester [prepared from 4-ethoxy-L-proline by the procedure described in J.Am. Chem. Soc., 82, 3359 (1960) for L-proline] for the L-proline tert-butyl ester and acetylthioacetyl chloride for the 3-acetylthio-2-methylpropanoyl chloride in the procedure of Example 1, and then submitting the product to the procedure of Example 2, (±)-4,5-dihydro-4-ethoxy-(2-mercapto-1-oxopropyl)-1H-pyrrole-2-carboxylic acid is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04198515 |
| 出典データセット | uspto-grants-1980_04 |
| ORD ID | ord-39828a7f692944c8b50f025755bc436a |
| 出典メモ | uspto-grants-1980_04 |