2-Chloropropane → HCID 54222836, compound

Participants

Reaction Conditions

Reaction Steps

26.4 g (1.1 gram atom) of magnesium shavings and 100 ml of anhydrous ether are added to a round flask which is provided with a stirrer, condenser, thermometer and dropping funnel. There is now slowly added thereto a solution of 90.2 g (1.15 mol) of isopropyl chloride in 150 ml of ether. After completion of the addition, the mixture is held at reflux temperature for a further 1 hour. There are now added thereto at a temperature of 10° C. 126.2 g (1 mol) of 3,5-dimethyl-2-hexenal dissolved in 250 ml of anhydrous ether. The mixture is held at reflux temperature for 3 hours, then cooled down to 0° C. and decomposed by the addition of 370 ml of 10% ice-cold hydrochloric acid. The ethereal solution is washed neutral with water and dried, and the solvent is evaporated. There are thus obtained 168 g of crude material, fractional distillation of which yields 123.7 g (72.6%) of 2,5,7-trimethyl-4-octen-3-ol of boiling point 78°-79° C./5 mmHg; nD20 =1.4526.

Provenance & Evidence