Thionyl Chloride → HCID 20343950, compound

Participants

Reaction Steps

A suspension of 3.4 g of 1-acetyl-4-(2-phenylthiophenyl)piperidine-4-carboxylic acid, Example 15, in 5 ml of freshly distilled thionyl chloride is warmed on a steam bath for 5 minutes, effecting a clear solution. The excess thionyl chloride is removed at 50° C. under reduced pressure. The residue is recrystallized from a benzene-cyclohexane mixture to provide 1-acetyl-4-(2-phenylthiophenyl)piperidine-4-carbonyl chloride.

Provenance & Evidence