Hydrogen Bromide → HCID 70594250, compound

Participants

Reaction Steps

A mixture of 0.67 g of 4-ethoxycarbonyl-4-(2-phenylthiophenyl)piperidine, free base of Example 17, 0.48 g of 2-bromoethylbenzene, 0.65 g of sodium bicarbonate and 0.65 g of potassium iodide in 15 ml of dimethylformamide is stirred at 60°-70° C. for 16 hours. Thereafter, the mixture is diluted with ether and the diluted mixture is filtered. The filtrate is concentrated in vacuo. The residue is purified by column chromatography (alumina column, ether eluant) to provide a purified product which, in ether, is converted to its hydrobromic acid salt. The salt is recrystallized from an acetone-ether mixture to provide 4-ethoxycarbonyl-1-phenylethyl-4-(2-phenylthiophenyl)piperidine hydrobromide.

Provenance & Evidence