Acetic Anhydride → HCID 20343984, compound

Participants

Reaction Steps

A mixture of 0.7 g of 4-[2-(4-fluorophenylthio)phenyl]-piperidine-4-carboxylic acid, free amino acid of Example 30, and 0.83 ml of acetic anhydride in 4.2 ml of pyridine is stirred at reflux for 4 hours. Thereafter, the excess pyridine is removed by rotary evaporation and the residue is taken up in 10 ml of water and treated with 10 ml of 1 N hydrochloric acid. The acidic mixture is extracted thrice with 20 ml portions of an ether-benzene (1:1) mixture and the combined extracts are successively washed twice with 40 ml portions of water, once with 15 ml of saturated sodium chloride solution and dried. The resulting product is recrystallized from acetone-ether to provide 1-acetyl-4-[2-(4-fluorophenylthio)phenyl]piperidine-4-carboxylic acid.

Provenance & Evidence