Potassium Iodide → HCID 20344008, compound

Participants

Reaction Steps

A mixture of 2.8 g of 4-ethoxycarbonyl-4-(2-phenylthiophenyl)piperidine, free base of Example 17, 1.2 g of allyl bromide, 2.5 g of sodium bicarbonate and a crystal of potassium iodide in 30 ml of dimethylformamide is stirred at 70°-80° C. for 16 hours. Thereafter, the mixture is diluted with water and ether, and the ether layer is separated and then dried. The ether is removed in vacuo and the resulting product is purified by passing through an alumina column, eluted with ether. The purified product is converted in ether to its oxalic acid salt. The salt is recrystallized from a methyl alcohol-acetone-ether mixture to provide 1-allyl-4-ethoxycarbonyl-4-(2-phenylthiophenyl)piperidine oxalate.

Provenance & Evidence