Sodium hydride → HCID 53883952, compound

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Reaction Steps

21.7 g (0.1 mole) 7-chloro-2-hydroxydibenzofuran is dissolved in 200 ml of tetrahydrofuran. To this solution is added 5.2 g sodium hydride (50% dispersion in oil) which was prewashed in petroleum ether. After hydrogen evolution had ceased, the solution was brought to reflux and 11.2 g (0.1 mole) of 2-chloropropionamide was added. The mixture was allowed to reflux for 8 hours. The solvent was evaporated and the crude product was washed with dilute acid and crystallized from methanol to yield 14.5 g, m.p. 185°-187° C. This Example corresponds to Example 20 in Table I.

Provenance & Evidence