Water → Acetamide, N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)-

HRID 2049924Notes

Reaction equation

HRID 2049924 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]([NH:10][C:11](=[O:13])[CH3:12])[CH2:7][CH2:8][CH2:9][C:2]1=2.[OH2:14]>C(O)(=O)C>[O:14]=[C:9]1[C:2]2[S:1][CH:5]=[CH:4][C:3]=2[CH:6]([NH:10][C:11](=[O:13])[CH3:12])[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 962WaterHCID 4976773N-(4,5,6,7-Tetrahydrobenzo[b]thiophen-4-yl)acetamide

Product 1

HCID 106675Acetamide, N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)-Yield 79.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

In a 100 ml three-necked round bottomed flask is placed 1.0 g. of N-(4,5,6,7-tetrahydrobenz[b] thien-4-yl) acetamide, 5 ml each of H2O and glacial acetic acid, and 5.13 g. of solid cobaltic acetate (assay 23.56% Co(III) by weight) prepared by method of Example V). The mixture is stirred and heated to 60° C. for 11 hours under a nitrogen atmosphere. Treatment as in Example V yields 1.04 g. of material containing 79.6% of the desired product.

Workup

  1. customIn a 100 ml three-necked round bottomed flask is placed
  2. customTreatment as in Example V yields 1.04 g

Sources & evidence

ORD record
ord-b4ebef65c71b46f991b412b5e0df64fa
Source dataset
uspto-grants-1980_04
Patent number
US04199510

Reaction notes

Loading…