HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → Cholest-5-ene-1alpha,3beta-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | 1alpha,2alpha-Epoxycholesta-4,6-dien-3-one | HCID 13911108 | — |
| Solvent | Ammonia tetrahydrofuran | HCID 21982362 | — |
| Product | Cholest-5-ene-1alpha,3beta-diol | HCID 11112200 | — |
Reaction Steps
Barton et al, J.A.C.S. 95:8, 2748 (1973) describe reduction of 1α,2α-epoxycholesta-4,6-dien-3-one with large excesses of each of lithium metal and ammonium chloride in ammonia/tetrahydrofuran at reflux to obtain 1α,3β-dihydroxycholest-5-ene which is a precursor of 1α-hydroxyvitamin D3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04199518 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-250f3c695fcb4d3a877fa31be8259cad |
| Source note | uspto-grants-1980_04 |