Dicyclohexylamine → HCID 20342937, compound

HRID 2049955Notes

Reaction equation

HRID 2049955 reaction equation
C1(NC2CCCCC2)CCCCC1.C1(NC2CCCCC2)CCCCC1.[Br:27][C:28]1[CH:47]=[C:46]2[C:31]([NH:32][CH:33]=[C:34]2[CH2:35][CH:36]([C:43]([OH:45])=[O:44])[NH:37][C:38](=[O:42])[CH2:39][CH2:40][SH:41])=[CH:30][CH:29]=1>C(#N)C>[Br:27][C:28]1[CH:47]=[C:46]2[C:31]([NH:32][CH:33]=[C:34]2[CH2:35][CH:36]([C:43]([OH:45])=[O:44])[NH:37][C:38](=[O:42])[CH2:39][CH2:40][SH:41])=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 7582DicyclohexylamineHCID 20342944HCID 20342944, compound

Product 1

HCID 20342937HCID 20342937, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The 130 mg. of material that remains in the flask is dissolved in acetonitrile and treated with 1 equivalent of dicyclohexylamine. After standing several hours, the precipitate is filtered off and dried at 40° 1 mm to yield 200 mg. of 5-bromo-N-(3-mercapto-1-oxopropyl)-DL-tryptophan dicyclohexylamine salt; m.p. 198°-201°.

Workup

  1. waitAfter standing several hours
  2. filtrationthe precipitate is filtered off
  3. customdried at 40° 1 mm
  4. customto yield 200 mg

Sources & evidence

ORD record
ord-9ca4cd870e1a497dabf529780f23e265
Source dataset
uspto-grants-1980_04
Patent number
US04199512

Reaction notes

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