Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 20298673 | HCID 20298673 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 20298675 | HCID 20298675 | 79.4% |
Reaction Steps
A stirred solution of 4-[3-[4-methoxy-2-[[(2-phenylethyl)imino]methyl]phenoxy]propyl]-morpholine (41.7 g) in 190 ml. of methanol is reduced with 12.4 g of sodium borohydride (added portionwise). A cold water bath is used to maintain the temperature of the reaction mixture at 35° C. After 3 hours, the solvent is treated with water and the product is extracted two times with ether. The ether fractions are combined, treated with water, dried and concentrated to give 33.3 g of the title compound, boiling point 249°-254° C. at 0.3-0.4 mm of Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04199528 |
|---|
| Source dataset | uspto-grants-1980_04 |
|---|
| ORD ID | ord-44417a349053413d8dd82e4d183a26c7 |
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| Source note | uspto-grants-1980_04 |
|---|
