HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Methoxy-2-[3-(4-morpholinyl)propoxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Hydroxy-4-Methoxybenzaldehyde | HCID 69600 | — |
| Reactant | 4-(3-Chloropropyl)morpholine | HCID 95834 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Methoxy-2-[3-(4-morpholinyl)propoxy]benzaldehyde | HCID 20298681 | 65.8% |
Reaction Steps
2-Hydroxy-4-methoxybenzaldehyde (25 g) in 125 ml. of dimethylformamide is treated first with 8.2 g of 50% sodium hydride, then with 36 g of N-(3-chloropropyl)morpholine dissolved in 65 ml. of toluene, following the procedure described in Example 1A, yielding 30.2 g of the title compound, boiling point 190°-195° C. at 0.1-0.2 mm of Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04199528 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-e44ff88d1384475592a55f973413afac |
| Source note | uspto-grants-1980_04 |