HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [1-(1,3-Dibutylxanthin-7-yl)methyl]dimethylphosphine Oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phosphine oxide, (chloromethyl)dimethyl- | HCID 74224 | — |
| Reactant | 1,3-Dibutylxanthine | HCID 101421 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [1-(1,3-Dibutylxanthin-7-yl)methyl]dimethylphosphine Oxide | HCID 19689263 | — |
Reaction Steps
5 g (0.01 9 mol) of 1,3-dibutylxanthine were stirred at 80° C. for 6 hours with 2.88 g (0.0228 mol) of chloromethyldimethylphosphine oxide and 3.2 g (0.0228 mol) of potassium carbonate in 80 ml of DMF. The solution was cooled to room temperature and filtered, and the filtrate was concentrated under reduced pressure. The residue which remained was crystallized in petroleum ether/ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728686 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-20ece88fc4e64225b2c8a9f117afb490 |
| Source note | uspto-grants-1998_03 |