4-Pyrimidinamine, 2,6-dichloro- → 4-Amino-6-chloro-2-methoxypyrimidine

4-Amino-2,6-dichloropyrimidine (0.5 g.) was added to 30 ml. of a 1% solution of sodium methoxide in methanol. The resultant solution was heated at the reflux temperature for 2 hrs. The methanol was then removed by evaporaion and water was added to the residual oil. The precipitate that formed was filtered off, washed with water and dried at 100° C. at a pressure of 100 mm for 18 hrs. There was thus obtained 4-amino-6-chloro-2-methoxypyrimidine having a melting point at 124° C.

1. customThe methanol was then removed by evaporaion and water
2. additionwas added to the residual oil
3. customThe precipitate that formed
4. filtrationwas filtered off
5. washwashed with water
6. customdried at 100° C. at a pressure of 100 mm for 18 hrs
7. customat 124° C.

ORD record

ord-cf59b61295714ddf93cd82640b245032

Source dataset

uspto-grants-1980_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04199583