HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-Methyl-L-phenylalanine 2-propylthioethylamide trifluoracetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | t-Butyloxycarbonyl-N-methyl-L-phenylalanine 2-propylthioethylamide | HCID 54376676 | — |
| Solvent | Chloroform methanol acetic acid water | HCID 21923999 | — |
| Product | N-Methyl-L-phenylalanine 2-propylthioethylamide trifluoracetate | HCID 70584182 | — |
Reaction Steps
The protected amide from (a)(1.4 g) was deprotected with aqueous trifluoroacetic acid (10 ml) as in Example 7(b). Chromatography on silica in chloroform:methanol:acetic acid: water 120:36:2:3 gave a gum (1.1 g). Rf3A=0.61, Rf7B=0.71
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04199568 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-e9d45e3864d8442f8eba22b7ea8ef644 |
| Source note | uspto-grants-1980_04 |