Azobisisobutyronitrile → HCID 20343345, compound

Participants

Reaction Conditions

Reaction Steps

48.4 g (0.22 mol) of 3-(3-fluorophenoxy)-6-fluorotoluene were dissolved in 300 ml of anhydrous carbon tetrachloride and heated under reflux with 41 g of N-bromosuccinimide. After 70° C. was reached, 3 g of azo-diisobutyronitrile were added; after about 10-20 minutes the reaction commenced, with evolution of heat, and after the exothermic reaction had subsided the mixture was heated under reflux for a further 4 hours. The reaction batch was then cooled to 10° C., the succinimide was filtered off and the carbon tetrachloride was distilled off in vacuo. The oil which remained was distilled at 142°-150° C./2 mm Hg. 3-(3-Fluorophenoxy)-6-fluorobenzyl bromide was obtained in 51% yield.

Provenance & Evidence