Sodium Hydroxide → HCID 12898561, compound

HRID 2050071Notes

Reaction equation

HRID 2050071 reaction equation
[NH2:1][C:2]([C:11]1[CH:22]=[C:21]([CH3:23])[C:14]([O:15][CH2:16][C:17]([O:19]C)=[O:18])=[C:13]([CH3:24])[CH:12]=1)([C:7]([F:10])([F:9])[F:8])[C:3]([F:6])([F:5])[F:4].[OH-].[Na+]>C(O)C>[NH2:1][C:2]([C:11]1[CH:22]=[C:21]([CH3:23])[C:14]([O:15][CH2:16][C:17]([OH:19])=[O:18])=[C:13]([CH3:24])[CH:12]=1)([C:3]([F:6])([F:5])[F:4])[C:7]([F:10])([F:9])[F:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12898560HCID 12898560, compound

Product 1

HCID 12898561HCID 12898561, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Combine methyl 2-[4-(2-aminohexafluoro-2-propyl)-2,6-dimethylphenoxy]acetate (7.2 g=20 mmol) with 150 ml ethanol and 30 ml 1.0 N sodium hydroxide. Reflux 30 minutes and concentrate. Add 30 ml 1 N HCl and extract with ether. Dry and concentrate the ether. Sublime at 130° C./0.1 mm pressure to obtain as a while solid, 2-[4-(2-aminohexafluoro-2-propyl)-2,6-dimethylphenoxy]acetic acid, m.p. 138° C.

Workup

  1. temperatureReflux 30 minutes
  2. concentrationconcentrate
  3. additionAdd 30 ml 1 N HCl
  4. extractionextract with ether
  5. customDry
  6. concentrationconcentrate the ether

Sources & evidence

ORD record
ord-e0dc1518a0fa48698fa280f57b950658
Source dataset
uspto-grants-1980_04
Patent number
US04199597

Reaction notes

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