Thionyl Chloride → HCID 20343321, compound

Participants

Reaction Steps

A stirred mixture of 20.00 g (0.0680 mol) of 3-methyl-2-[p-(1,1,2,2-tetrafluoroethoxy)phenyl]butyric acid, 20.00 ml (33.2 g, 0.280 mol) of thionyl chloride (Baker), and 75 ml of dried benzene is refluxed for 4 hours. The reaction mixture is then evaporated and the resulting residue is diluted with 50 ml of benzene and again evaporated to give 22.46 g (106%) of a clear dark brown liquid. This product is used as is in the subsequent reactions. The liquid is examined by infrared analysis and determined to be the above-named product.

Provenance & Evidence