Pyridine → HCID 20343304, compound

Participants

Reaction Steps

To a stirred mixture of 6.81 g (0.0340 mol) of m-phenoxybenzyl alcohol, 3.0 ml (2.95 g, 0.0372 mol) of dried pyridine, and 20 ml of methylene chloride is added over a period of 20 minutes a 20 ml methylene chloride solution of 10.6 g (0.034 mol) of 3-methyl-2-[p-(1,1,2,2-tetrafluoroethoxy)phenyl]butyryl chloride. The reaction mixture is stirred at room temperature for 66 hours and then diluted with 200 ml of ether. The ether solution is washed with 200 ml of 20% hydrochloric acid and 200 ml of water, dried with sodium sulfate, filtered, and then evaporated to give 16.24 g (100%). This product is purified on a silica gel dry column (116 cm×5 cm, eluent=1:1 hexane-methylene chloride) by collecting a sample between 85 cm and 63 cm (solvent front=113 cm) to give 12.60 g (78%) of a clear slightly yellow colored oil.

Provenance & Evidence