HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 3-Fluoro-4-methoxyphenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | Trihexylamine | HCID 66022 | — |
| Reactant | 4-(Bromomethyl)-2-fluoro-1-methoxybenzene | HCID 2774553 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Fluoro-4-methoxyphenylacetonitrile | HCID 136251 | — |
Reaction Steps
A mixture of 4-(bromomethyl)-2-fluoroanisole (45.8 g, 0.21 mol), trihexylamine (1.4 g) and sodium cyanide (20.5 g, 0.42 mol) in water (50 ml) is heated at 60°-65° C. for 18 hours. The mixture is cooled and extracted in its ether, washed with water, saturated sodium chloride solution and dried (CNa2SO4). Evaporation of the solvent gives a solid, (33.2 g): m.p. 42°-46° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04199595 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-0b5c1373a8294b4196cf6dbc99e9e2f5 |
| Source note | uspto-grants-1980_04 |