反应详情

10 Grams of solanesol were dissolved in 50 ml of pyridine and the solution was added dropwise with of 15% solution of 4.6 g of cyclohexylcarboxylic acid chloride in pyridine over 30 minutes. After completion of the addition, the mixture was stirred at room temperature for two hours to complete the reaction. Then, the reaction product was diluted with n-hexane, washed with water and concentrated. The concentrate was purified by chromatography with 80 g of silica gel in n-hexane/benzene solvent mixture as elution solvent to obtain the final product as a white solid (m.p. 34.0°-35.0° C.). Yield: 6.2 g.

1. additionAfter completion of the addition
2. customthe reaction
3. washwashed with water
4. concentrationconcentrated
5. customThe concentrate was purified by chromatography with 80 g of silica gel in n-hexane/benzene solvent mixture as elution solvent