Hydrochloric Acid → HCID 20341792, compound

Participants

Reaction Steps

In 1 liter of methanol were suspended 275 g of 1-benzoyloxy-3-nitro-4-(dodecylcarbamoylmethoxy)benzene and 50 g of sodium hydroxide were added to the suspension at room temperature under stirring. After stirring for 30 minutes, the reaction solution was poured into 3 liters of ice water to which 150 ml of concentrated hydrochloric acid had been added. Extraction with 3 liters of ethyl acetate was effected and the ethyl acetate layer was washed three times with 3 liters of 5% aqueous sodium bicarbonate solution, dried over sodium sulfate and concentrated. The residual crystal was washed with acetonitrile. The yield was 203 g and the melting point was 150°-151° C. (acetonitrile).

Provenance & Evidence