Cysteamine Hydrochloride → 1-Nitro-2-(2-propynylamino)-2-(2-mercaptoethyl)ethylene

HRID 2050141Notes

Reaction equation

CS[C:3]([NH:8][CH2:9][C:10]#[CH:11])=[CH:4][N+:5]([O-:7])=[O:6].Cl.N[CH2:14][CH2:15][SH:16]>>[N+:5]([CH:4]=[C:3]([NH:8][CH2:9][C:10]#[CH:11])[CH2:14][CH2:15][SH:16])([O-:7])=[O:6]

Participants

Reactant 2

HCID 9082Cysteamine Hydrochloride

HCID 71401969N-[1-(Methylsulfanyl)-2-nitroethenyl]prop-2-yn-1-amine

Product 1

HCID 736839981-Nitro-2-(2-propynylamino)-2-(2-mercaptoethyl)ethylene

Procedure

A solution of the product of Step A of Example 2 is reacted with about an equimolar amount of cysteamine hydrochloride and about one equivalent of base, to produce 1-nitro-2-(2-propynylamino)-2-(2-mercaptoethyl)ethylene.

Sources & evidence

ORD record: ord-babc02473e4e485391d68fddd197e0e8
Source dataset: uspto-grants-1980_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04200578

Reaction notes

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