Pyridine → HCID 20342262, compound

HRID 2050172Notes

Reaction equation

HRID 2050172 reaction equation
[CH3:1][O:2][CH:3]([NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[OH:16])[C:4]([Cl:7])([Cl:6])[Cl:5].N1C=CC=CC=1.[C:24](Cl)(=[O:26])[CH3:25]>O>[CH3:1][O:2][CH:3]([NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[O:16][C:24](=[O:26])[CH3:25])[C:4]([Cl:7])([Cl:6])[Cl:5]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 20342263HCID 20342263, compound

Product 1

HCID 20342262HCID 20342262, compoundYield 77.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 2.5 g of N-(1'-methoxy-2',2',2'-trichloroethyl)-2-hydroxy benzamide was added 20 g of pyridine and maintained at below -10° C., 1.5 g of acetyl chloride was added dropwise and then allowed at room temperature for about 30 minutes, and poured into water to give a crystal which was recrystalized by using methanol to obtain 2.2 g white crystal of N-(1'-methoxy-2',2',2'-trichloroethyl)-2-acetoxy benzamide.

Workup

  1. temperaturemaintained at below -10° C.
  2. customto give a crystal which
  3. customwas recrystalized

Sources & evidence

ORD record
ord-8151c5e5f86544dc9b88cbcb724378ad
Source dataset
uspto-grants-1980_04
Patent number
US04200632

Reaction notes

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