Hydrochloric Acid → HCID 20342251, compound

Participants

Reaction Steps

To a solution of 3.347 g (16.5 mmoles) of 1-benzoyl-2-formylpyrrolidine in a mixture of 28 ml of tetrahydrofuran and 19 ml of water are added 1.30 g (20 mmoles; 1.23 equivalents) of potassium cyanide and 1.4 ml (16.7 mmoles) of concentrated hydrochloric acid. After 1 hour, the mixture is diluted with water and extracted with chloroform. The organic layer is separated, washed with water, dried over sodium sulfate, and evaporated under reduced pressure to yield 3.8 g of crude crystalline 2-hydroxy-2-(1-benzoylpyrrolidin-2-yl)acetonitrile in quantitative yield.

Provenance & Evidence