HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(benzo[b]furan-4-yloxy)-3-beta-(N-benzylcarbamoyl)ethylamino-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-(Benzo[b]furan-4-yloxy)-2,3-epoxypropane | HCID 13064032 | — |
| Reactant | beta-benzylamino-N-benzylpropionamide hydrochloride | HCID 20342449 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-(benzo[b]furan-4-yloxy)-3-beta-(N-benzylcarbamoyl)ethylamino-2-propanol | HCID 70593231 | — |
Reaction Steps
In a similar manner to that described above but using a mixture of 1-(benzo[b]furan-4-yloxy)-2,3-epoxypropane (1.9 g.), β-benzylamino-N-benzylpropionamide hydrochloride (3.05 g.), sodium hydrogen carbonate (0.84 g.), water (5 ml.) and isopropanol (40 ml.) there is obtained 1-(benzo[b]furan-4-yloxy)-3-β-(N-benzylcarbamoyl)ethylamino-2-propanol, m.p. 109°-110° C. The β-benzylamino-N-benzylpropionamide hydrochloride used as starting material may also be prepared in the manner described above, m.p. 237°-239° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04200652 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-f6849f2aca9748d4aab7cac99d2189a5 |
| Source note | uspto-grants-1980_04 |