Thionyl Chloride → HCID 20506262, compound

HRID 2050279Notes

Reaction equation

HRID 2050279 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH2:15][CH2:16]O)([O-:3])=[O:2].S(Cl)([Cl:20])=O>ClC(Cl)Cl>[Cl:20][CH2:16][CH2:15][NH:14][C:5]1[CH:6]=[CH:7][C:8]([C:10]([F:13])([F:12])[F:11])=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 2799157HC Yellow no. 13

Product 1

HCID 20506262HCID 20506262, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a stirred mixture of 12.5 parts of 2-{[2-nitro-4-(trifluoromethyl)phenyl]amino}ethanol and 150 parts of trichloromethane are added dropwise 7.5 parts of sulfinyl chloride. Upon completion, stirring is continued for 2 hours at reflux temperature. The reaction mixture is evaporated and the residue is crystallized from 2,2'-oxybispropane. The product is filtered off and dried, yielding N-(2-chloroethyl)-2-nitro-4-(trifluoromethyl)benzenamine.

Workup

  1. temperatureat reflux temperature
  2. customThe reaction mixture is evaporated
  3. customthe residue is crystallized from 2,2'-oxybispropane
  4. filtrationThe product is filtered off
  5. customdried

Sources & evidence

ORD record
ord-6fd34a767fa7479dae67185670e48c8f
Source dataset
uspto-grants-1980_04
Patent number
US04200641

Reaction notes

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